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Pueraria mirifica & Sea Collagen hydrolysate

  Organically cultivated Pueraria mirifica with Sea Collagen hydrolysate

A powerful combinaion of natural health supplements for super anti-aging benefits

  Organically cultivated Pueraria mirifica with Sea Collagen hydrolysate Organically cultivated PM 200 mg with Sea collagen 200 mg per V-cap
$29.95 + $6.00 shipping. organically cultivated Siam Natural  Pueraria mirifica w/ Sea Collagen hydrolysate 100 ea 400mg V-caps! Next day shipments worldwide

Pueraria mirifrica & Sea Collagen hydrolysate
Collagen is the most abundant protein in animals which is found in skin & bones. Approximately 1/3 of the protein in the hunman body is collagen. Collagen plays a key role in providing the structural scaffold surrounding cells that helps to suppport the cell shape. Collagen mainly provides flexibility and forms strong structure for our skin, connective tissue, and bones. It has a strong tightly wound triple-helix molecular structure, so the strength of the collagen structure itself can be as strong as steel wire.

Collagen is a protein that can be produced by our body naturally, however we gradually produce less collagen as we age. Collagen in our bodies diminishes at the rate of 1.5% per year from age 25 years onward. That's why we have wrinkles, weakened bones and poor mobility as we age. Numerous studies recommend daily intake of external collagen as a supplement to maintain a healthy body structure condiion. Because of the strong firerous structure, the human body has difficulty breaking down protein in our diet to produce the raw collagen we need. Our Siam Natural Sea (fish) Collagen [hydrolysate] is already broken down so the body utilizes 100% of what you take. It's extremely beneficial to skin, hair, joints, bones and cartilage.

• Hair
• Skin tissue
• Muscle
• Cartilage
• Ligaments
• Blood cell growth

Some doctors are referring to Sea Collagen Hydrolysate as the new anti-aging product of the century

Depletion of collagen in the skin leads to the formation of wrinkles and the appearance of aging, which is why you've probably heard of
collagen in relation to anti-aging products. Depletion of collagen in connective tissue, which often occurs naturally as a result of age, can
contribute to such conditions as arthritis and musculo-skeletal injuries due to a lack of support for the joints.

Fish Collagen – Type I is the most abundant of the many types of Collagen and are found in bones, tendons, skin and tissues.
Studies support that collagen peptides type I extracted from fish consist of small peptide molecules that have a superior bioavailability
and digestibility compare to other collagen products. Due to smaller molecular weight, it is absorbed at a higher level through the intestinal
barrier into the bloodstream and carried throughout the body, leading to the collagen synthesis in the joint tissues, bones and skin dermis.

Hydrolyzed Collagen is the missing link in supplying amino acids like glycine, proline and lysine that are required by the body to build connective tissue to regulate cell growth.
Fish collagen peptides are also characterized by their specific amino acid composition, with a high concentration of glycine, proline and
hydroxyproline. These amino acids have nutri-functional properties supporting health and beauty. Hydroxyproline peptides such as
Pro-Hyp or Hyp-Gly stimulate cells in the skin, joints and bones, and leads to collagen synthesis through cell activation, suppression and growth.
In particular, the amount of Hyp-containing peptide such as in the fish scale is significantly higher after ingestion than in any other form of collagen and can be detected in the blood.

Collagen is one of the most important structural constituents in our bodies, representing 1/15 of our total body weight. This fiber-shaped protein plays an extremely important role in ensuring the cohesion, elasticity and regeneration of skin, bones, tendons, ligaments and skeletal muscles accounting for 25 to 30% of its total protein – 75% of our skin is collagen. It is the key component for supple and radiant healthy skin.

As we age, our body loses its ability to make collagen, thus, it starts to break down. This is why skin sags and wrinkles: hair becomes thinner, dull, or lifeless; joints are stiffer and less flexible; and bodies become softer and have less tone.
Diet, age, stress, digestive system, &physical activity all affect our ability to provide the body with the nutritional raw materials it requires.
Supplementing with collagen protein is believed to provide the body with the amino acids necessary to manufacture and support collagen in order to remain healthy and active.

Siam NaturalSea Collagen is uniquely formulated with 18 amino acids, zero fat, and no chemical preservatives & contains the following;
Alanine, Glutamic acid, Hydroxy Proline, Proline, Tryptophan, Arginine, Glycine, Isoleucine, Methiocine, Serine, Tyrosine, Aspartic Acid,
Histidine, Leucine, Phenylalanine, Theronine, Valine, Lysine."

Pueraria mirifica - ethnopharmacology:

Pueraria mirifica is an indigenous Thai herbal medicine known in Thai as “Kwao Krua” (spelling in different ways: Kwao Kreu, Kwao Keur, Kwao Kruea) which is normally referred to “white Kwao Krua” or “Kwao Krua Khao”. The tuberous root of this plant, containing various phytoestrogens, has been used in folk medicine by Thai people for a long period of time as a rejuvenating agent and as the agent for inducing breast enlargement. Folklore goes on to say that the root is a “fountain of youth” for aged men and women.

Scientific Information
Bioactivity: Phytoestrogenic activity, rejuvenating function

Bioactivity study:
There are many reported on estrogenic properties in vitro and in vivo assay which exhibited estrogenic effects with metabolic activation of the KwaoKruaKhao plant and without adverse effects on animals and humans. Pueraria mirifica extract showed a biphasic response to MCF-7 cells with astrong binding with estrogen at high dose in competition with estrogen receptors. High concentrations of the plant extract had an anti-proliferation effect on HeLacancer cells. A tuberous plant contains large amounts of isoflavonoids, especially puerarin and daidzein. It is popular for consumption in the treatment of hypertension and alcoholism with antioxidant and has shown anti-dipsotropic activities. At present, Puerariamirifica is used as the main botanical ingredients in cosmetics and dietary supplement products.

In particular, Pueraria mirifica Airy Shaw et Suvatabhandu (Leguminosae), which contains high amounts of isoflavones, has been extensively studied for its content, and estrogenic effects on reproductive organs and bones. Most in vivo studies evaluating the estrogenic effects of phytoestrogens in P. mirifica used rodents as experimental. A number of laboratories in the US and Europe have reported that commercially available rodent dietary formulations contain variable but significant levels of phytoestrogens, especially daidzein and genistein.

Chemical constituents:

The tuberous root of Puerariamirifica contains miroestrol and other various active principles, namely, deoxymiroestrol, daidzin, daidzein, genistin, genistein, puerarin, coumestrol, mirificoumestan, kwakhurin, mirificin and two steroids, estrone and estriol.
Deoxymiroestrol was recently isolated and identified as the actual, most active phytoestrogen of the plant. Up to now, the plant material being used in most studies on Pueraria mirifica was either the dried powder or the alcohol extract.

Quality control:

Puerarin, Daidzein, Daidzin, Genistin, Genistein were isoflavones which was used for standardizationof crude extract by HPLC
method and HPLC and TLC fingerprintsalso use for control a quality.

Reference(Only major cite)
A. Manosroi, J. Manosroi.,Determination of bioactive compounds in roots of
different ages Puerariamirifica, Airy Shaw Suvatabhandhu and
ButeasuperbaRoxb. from various location in Thailand, Pharmaceutical-
Cosmetic Raw Materials and Natural ProductsResearch and
Development Center (PCRNC) Institute for Science and Technology
Research and Development
W. Cherdshewasart, S. Subtang, W. Dahlan,.(2007).
Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirificain comparison
with Puerarialobata. Journal of Pharmaceutical and Biomedical
Analysis.43; 428–434
Puerarin Miroestrol Deoxymiroestrol
Daidzin Daidzein Genistin Genistein

S.Wattanapitayakul, L. Chularojmontri, S.Srichirat, (2005). Effects of Pueraria Mirificaon Vascular Function of Ovariectomized Rabbits.J Med Assoc Thai.88; Suppl.1
S. Okamura, Y. Sawada, T. Satoh, H. Sakamoto, Y. Saito, H. Sumino,T. Takizawa, T.Kogure, Ch.Chaichantipyuth, Y. Higuchi, Ts. Ishikawaand T.Sakamaki (2008). PuerariaMirificaPhytoestrogens Improve Dyslipidemia in Postmenopausal Women Probably by Activating Estrogen Receptor Subtypes. Tohoku J. Exp. Med.216, 341-351
W. Cherdshewasart, W. Sutjit, K. Pulcharoen and M. Chulasiri (2009). The mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Puerarialobata.Braz J Med Biol Res, 42(9); 816-823
N.Urasopona, Y.Hamadad, K.Asaokae, U.Poungmalic, S.Malaivijitnond (2008).Isoflavone content of rodent diets and its estrogenic effect on vaginal cornification in Pueraria mirifica-treated rats.ScienceAsia34; 371–376



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